Respiratory failure & ventilation
Safety of Enteral Feeding in Patients on High-Flow Nasal Cannula
Authors' conclusion
In this single-center, retrospective cohort, enteral nutrition in patients on HFNC was associated with lower risk of progression of respiratory failure and was not associated with increased risk of poor clinical outcomes.
Study context
- Population
- Hospitalised adults treated with high-flow nasal cannula (HFNC) at a tertiary academic hospital, 2020–2022; excluding chronic TPN, chronic tracheostomy, total laryngectomy, DNI statusprimary analysis
- Participants
- 220 adults
- Exposure
- Enteral feeding vs NPO in adults on HFNC
- Outcome
- Progression of respiratory failure from HFNC to noninvasive positive pressure ventilation, mechanical ventilation or ECMO
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Progression of respiratory failure
Enteral feeding vs NPOOdds ratio (95% CI)P value
Multivariate mixed effects linear regression model
0.33(0.18–0.58)
P < 0.001Propensity score-matched analysis
0.30(0.15–0.58)
P < 0.001Observational data: associations, not effects.
Original publication
Safety of Enteral Feeding in Patients on High-Flow Nasal Cannula. Crit Care Med. Published 18 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →