Seizure after flumazenil reversal for total intravenous anaesthesia with remimazolam versus propofol: a matched retrospective cohort analysis of a large Japanese nationwide inpatient database
Main findingResult — go to the resultAdjusted odds ratio 1.08 95% CI 0.49–2.37Authors' conclusion
We observed no significant differences in perioperative seizures between remimazolam-flumazenil and propofol in patients undergoing non-neurological surgery.
Study context
- Population
- Patients undergoing elective surgery (excluding brain surgery) with TIVA, Japanese Diagnosis Procedure Combination database, April 2020–March 2022matched cohort of 19,105
- Exposure
- TIVA with remimazolam-flumazenil vs propofol
- Outcome
- Perioperative seizures
Methodological detailsmatched cohort, nationwide inpatient database, conditional logistic regression
- Matched cohort
- Nationwide inpatient database
- Conditional logistic regression
Main finding
As reported in the abstract
Adjusted odds ratio
1.08
95% CI 0.49–2.37
Remimazolam-flumazenil vs Propofol
aOR 1.08 (95% CI 0.49–2.37)
Observational data: associations, not effects.
Further findings
Crude incidence of seizures (overall)
- Crude seizure incidence
- 0.66% (95% CI 0.63-0.68%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Seizure after flumazenil reversal for total intravenous anaesthesia with remimazolam versus propofol: a matched retrospective cohort analysis of a large Japanese nationwide inpatient database. Br J Anaesth. Published 6 February 2025. doi:10.
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