Cardiothoracic & vascular anesthesia
Serum creatinine is an unreliable marker of renal function in patients undergoing heart transplantation
Authors' conclusion
eGFR underestimated mGFR and the agreement between eGFR and mGFR was low with an unacceptably large between-group error and low accuracy. Furthermore, the ability of eGFR to assess changes in mGFR, postoperatively, was poor.
Study context
- Population
- Patients undergoing heart transplantation (Htx), single centre
- Participants
- 55 patients
- Exposure
- eGFR vs mGFR
- Outcome
- Accuracy of eGFR to predict mGFR (% of patients with eGFR within 30% of mGFR, P30)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Accuracy and agreement of eGFR vs mGFR
Accuracy (P30)
52%
Bias (mL/min/1.72 m²)
11.2 ± 17.4
Limits of agreement (mL/min/1.72 m²)
−23.0 to 45.4
Error
58%
Observational data: associations, not effects.
Further findings
Trending ability: concordance rate between eGFR and mGFR changes (four-quadrant plot)
- Concordance rate
- 72%
Original publication
Serum creatinine is an unreliable marker of renal function in patients undergoing heart transplantation. Acta Anaesthesiol Scand. Published 27 February 2024. doi:10.
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