Cardiothoracic & vascular anesthesia
Severe Postoperative Bleeding after Heart Transplantation
Authors' conclusion
This study reports a high incidence of severe hemorrhagic complications after heart transplantation, particularly in patients with mechanical circulatory support. Bleeding complications were associated with a significant increase in morbidity and mortality.
Study context
- Population
- Adults receiving a heart transplant, 2015–2022, two French referral centers
- Participants
- 446 adults
- Outcome
- Incidence of severe bleeding complications (Universal Definition of Perioperative Bleeding score ≥3)
Methodological detailsmulticentre (two French referral centers), multivariable logistic regression, multivariable Cox regression
- Multicentre (two French referral centers)
- Multivariable logistic regression
- Multivariable Cox regression
Main finding
As reported in the abstract
Severe bleeding (Universal Definition of Perioperative Bleeding score ≥3)
Patients who developed severe bleeding
112
25%
Observational data: associations, not effects.
Further findings
Variables associated with severe bleeding (multivariable analysis)
| adjOR (95% CI) | ||
|---|---|---|
| Long-term mechanical cardiac support | 2.21 (1.01–4.88) | |
| Preoperative hemoglobin | 0.85 (0.76–0.95) | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | Estimate | P value | |
|---|---|---|---|
| Variables associated with severe bleeding (multivariable analysis)CPB duration (per 10-min increase) | adjOR 1.08 (95% CI 1.03–1.15) | ||
| Mortality, severe bleeding vs no severe bleeding · 1 yrMultivariable Cox regression | aHR 1.91 (95% CI 1.18–3.09) | P = 0.008 | |
| 0.20.5125Ratio (log scale) |
Mortality, severe bleeding vs no severe bleeding · 1 yr · unadjusted
P < 0.001
Original publication
Severe Postoperative Bleeding after Heart Transplantation. Anesthesiology. Published 13 January 2026. doi:10.
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