Cardiothoracic & vascular anesthesia
Perioperative management of adult sickle cell disease patients requiring cardiac surgery: A 25-year experience in a referral center
Authors' conclusion
Despite the acute stress associated with CPB, adult SCD patients experienced acceptable postoperative complications and showed reasonable long-term outcomes when managed with careful preoperative HbS optimization and a multidisciplinary approach.
Study context
- Population
- Adult sickle cell disease (SCD) patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), French referral center, 1996–2021
- Participants
- 21 patients · 29 procedures
- Outcome
- Perioperative management, complications and outcomes
Methodological detailssingle referral centre
- Single referral centre
Main finding
As reported in the abstract
- Age, years
- 36 [28-43]
- Baseline hemoglobin S (HbS) fraction, %
- 67 [56-83]
- Baseline hemoglobin, g/dL
- 9 [8-9]
- HbS after preoperative transfusion management, %
- 25 [21-29]
- Hemoglobin after preoperative transfusion management, g/dL
- 10 [10-11]
- Valvular repair or replacement, procedures
- 23
- Heart transplantation, procedures
- 3
- Procedures requiring intraoperative RBC transfusion
- 26
- RBC units administered
- 4 [3-6]
- Minimum intraoperative temperature, °C
- 35.0 [34.4-35.8]
- Minimum intraoperative PaO2, mmHg
- 192 [169-207]
- Minimum intraoperative hematocrit, %
- 19 [18-20.5]
- Maximum lactate during CPB, mmol/L
- 3.5 [2.9-5.1]
- ICU LOS, days
- 5 [3-9]
- 1-year survival
- 85.7%
- 5-year survival
- 64.0%
- 10-year survival
- 54.9%
Observational data: associations, not effects.
Further findings
Preoperative transfusion management: HbS fraction and hemoglobin
- Baseline HbS fraction
- 67 [56-83] %
- Baseline hemoglobin
- 9 [8-9] g/dL
- HbS after preoperative transfusion management
- 25 [21-29] %
- Hemoglobin after preoperative transfusion management
- 10 [10-11] g/dL
Intraoperative management
- Procedures requiring intraoperative RBC transfusion
- 26
- RBC units administered
- 4 [3-6]
- Minimum intraoperative temperature
- 35.0 [34.4-35.8] °C
- Minimum PaO2
- 192 [169-207] mmHg
- Minimum hematocrit
- 19 [18-20.5] %
- Maximum lactate during CPB
- 3.5 [2.9-5.1] mmol/L
Postoperative course
- ICU LOS
- 5 [3-9] days
- No vaso-occlusive crisis occurred
Long-term survival
- 1-year survival
- 85.7%
- 5-year survival
- 64.0%
- 10-year survival
- 54.9%
Original publication
Perioperative management of adult sickle cell disease patients requiring cardiac surgery: A 25-year experience in a referral center. Anaesth Crit Care Pain Med. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →