Cardiothoracic & vascular anesthesia
Sex Differences in Opioid Administration After Cardiac Surgery
Main finding · Cumulative OMEDResult — go to the resultAdjusted mean difference −33.21 mg 95% CI −47.05 to −19.36Authors' conclusion
Female sex was associated with significantly lower amounts of opioids administered after cardiac surgery.
Study context
- Population
- Adults after cardiac surgery, 2014 to 2019, tertiary academic referral center
- Participants
- 3,822 adults
- Exposure
- Women vs men
- Womenn = 1,032
- Menn = 2,790reference
- Outcome
- Cumulative oral morphine equivalent dose (OMED) for the postoperative admission
Methodological detailssingle-centre, tertiary academic referral center, multivariate regression adjusted for confounders
- Single-centre
- Tertiary academic referral center
- Multivariate regression adjusted for confounders
Main finding
Cumulative OMED
Adjusted mean difference
−33.21 mg
95% CI −47.05 to −19.36
P < 0.001
By group
Women vs Men
adjusted mean difference −33.21 mg (95% CI −47.05 to −19.36); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Odds ratio (95% CI) | P value | |
|---|---|---|---|
| Gabapentinoid administration | 1.91 (1.42–2.58) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Daily cumulative oral morphine equivalent dose (OMED), POD 1 to 5
- Cumulative OMED significantly lower in female patients on POD 1 to 5; greatest disparity on day 5
- aMD, −89.83 mg; 95% CI, −155.9 to −23.80 mg; p = 0.009
- Adjusted for confounders
Other nonopioid analgesics or specific types of opioid analgesics
- No association between patient sex and administration
Pain scores within first 48 hours after extubation; opioids administered in close proximity to pain assessments
- No association with patient sex
Original publication
Sex Differences in Opioid Administration After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 5 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →