Spontaneous recovery from rocuronium measured by mechanomyography during 100- or 200-Hz tetanic stimulations compared to normalized train-of-four with acceleromyography
Authors' conclusion
In anesthetized humans, mechanomyographic 200-Hz tetanic stimulation detects lighter levels of residual paralysis than NTOF and 100-Hz tetanic stimulation during a valuable additional period.
Study context
- Population
- Anesthetized patients under intravenous GA recovering spontaneously from rocuronium
- Participants
- 20 participants
- Exposure
- 100- vs 200-Hz tetanic stimulation vs acceleromyographic normalized TOF
- Outcome
- 100- vs 200-Hz tetanic fade ratios (residual force at end of contraction / maximal force during the 5 s), before rocuronium and at different recovery levels
Methodological detailswithin-patient comparison
- Within-patient comparison
Main finding
As reported in the abstract
Tetanic fade ratio, late recovery (NTOF ratio ≥ 0.9)
200-Hz
0.20
SD 0.23
100-Hz
0.64
SD 0.29
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
min
| Outcome | 100-Hz | 200-Hz |
|---|---|---|
| Delay from NTOF ratio 0.9 to tetanic fade ratio 0.9 | 7.7 (SD 7.1) | 43.6 (SD 14.6) |
Original publication
Spontaneous recovery from rocuronium measured by mechanomyography during 100- or 200-Hz tetanic stimulations compared to normalized train-of-four with acceleromyography. J Clin Monit Comput. Published 1 April 2025. doi:10.
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