The association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study
Main finding · 28-day mortalityResult — go to the resultHazard ratio 0.79 95% CI 0.65–0.96Authors' conclusion
In critically ill patients with sepsis, higher PaO2 (≥ 80 mm Hg) during the first three ICU days was associated with a lower 28-day mortality compared with conservative PaO2.
Study context
- Population
- Critically ill sepsis patients in the intensive care unit (ICU), Korean Sepsis Alliance nationwide registrypropensity-matched 1:1
- Participants
- 1,211 vs 1,211
- Exposure
- Liberal PaO2 vs conservative PaO2 over the first three ICU days
- Liberal PaO2n = 1,211
- Conservative PaO2n = 1,211reference
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailspropensity-score matched (1:1), nationwide registry
- Propensity-score matched (1:1)
- Nationwide registry
Main finding
As reported in the abstract
day 28
Hazard ratio
0.79
95% CI 0.65–0.96
P = 0.017
By group
Liberal PaO2
14.9%
Liberal PaO2 vs Conservative PaO2
HR 0.79 (95% CI 0.65–0.96); P = 0.017
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| ICU mortalityPropensity-score matched | 0.80 (0.67–0.96) | P = 0.019 | |
| Hospital mortalityPropensity-score matched | 0.84 (0.73–0.97) | P = 0.020 | |
| 0.512Hazard ratio (log scale) |
Median
| Outcome | Liberal PaO2 | Conservative PaO2 |
|---|---|---|
| PaO2 · ICU day 1 | 107.2 (range as printed 92.0–134.0) | 84.4 (range as printed 71.2–112.0) |
| PaO2 · ICU day 2 | — not stated in the abstract | 80.0 (range as printed 71.0–100.0) |
| PaO2 · ICU day 3 | 106.0 (range as printed 91.9–127.4) | 78.0 (range as printed 69.0–94.5) |
— not stated in the abstract
- PaO2: all p-values < 0.001
- PaO2: all p-values < 0.001
- PaO2: liberal day-2 median not legibly printed in the abstract
- PaO2: all p-values < 0.001
Prognosis with hyperoxia vs conservative oxygenation, by ICU day
- Hyperoxia associated with better prognosis on ICU day 2 (p-value = 0.007)
- Hyperoxia associated with better prognosis on ICU day 3 (p-value < 0.001)
- No association on ICU day 1
- Lowest 28-day mortality at PaO2 of around 100 mm Hg
Original publication
The association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study. Crit Care. Published 30 May 2024. doi:10.
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