Respiratory failure & ventilation
The effect of high‐flow nasal oxygen flow rate on gas exchange in apnoeic patients: a randomised controlled trial
Authors' conclusion
In conclusion, the rate of carbon dioxide accumulation in arterial blood did not differ significantly between apnoeic patients who received high-flow nasal oxygen and those who did not.
Study context
- Population
- Apnoeic patients at induction of anaesthesia, pre-oxygenated with HFNO at 50 l.min-1
- Participants
- 114 patients
- Comparison
- HFNO at 70 or 120 l.min-1 vs 0 l.min-1 during apnoea
Primary result
As reported in the abstract
PaCO2 rise, first minute of apnoea · first minute of apnoea
P = 0.16
Further findings
Rate of PaCO2 rise, minutes 2–4 of apnoea · second, third and fourth minutes of apnoea — 70 l.min-1, 120 l.min-1 vs 0 l.min-1 · across 3 groups
P = 0.17
PaO2 after 4 minutes of apnoea — 70 l.min-1, 120 l.min-1 vs 0 l.min-1 · across 3 groups
P < 0.001
Time to desaturate to 92% after onset of apnoea — 70 l.min-1, 120 l.min-1 vs 0 l.min-1 · across 3 groups
P < 0.001
Original publication
The effect of high‐flow nasal oxygen flow rate on gas exchange in apnoeic patients: a randomised controlled trial. Anaesthesia. Published 15 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →