Cardiothoracic & vascular anesthesia
The Effects of Corticosteroids on Survival in Pediatric and Nonelderly Adult Patients Undergoing Cardiac Surgery: A Meta-analysis of Randomized Studies
Pooled resultResult — go to the resultRelative risk 0.69 95% CI 0.52–0.92Authors' conclusion
This meta-analysis of randomized trials highlights the potential benefits of corticosteroids on survival in cardiac surgery for patients younger than 65 years old.
Study context
- Population
- Patients younger than 65 years (pediatric and non-elderly adults) undergoing cardiac surgery with CPB
- Participants
- 6,598 participants · 17 RCTs
- Comparison
- Perioperative corticosteroids vs placebo or standard care
- Corticosteroidn = 3,321
- Placebo or standard caren = 3,277reference
- Outcome
- Mortality
- Follow-up
- Longest available
Pooled result
As reported in the abstract
Relative risk
0.69
95% CI 0.52–0.92
P = 0.01
Events by group
Corticosteroid vs Placebo or standard care
RR 0.69 (95% CI 0.52–0.92); P = 0.01
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Highest postoperative vasoactive inotropic score (VIS)I2 = 0% | −2.07 (−3.69 to −0.45) | P = 0.01 | |
| −4−202Difference (linear scale) |
Safety
AKI, AF, myocardial injury, cerebrovascular events, infections
- No significant differences between the two treatment groups
Original publication
The Effects of Corticosteroids on Survival in Pediatric and Nonelderly Adult Patients Undergoing Cardiac Surgery: A Meta-analysis of Randomized Studies. J Cardiothorac Vasc Anesth. Published 5 July 2024. doi:10.
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