The efficacy and safety of ciprofol and propofol in patients undergoing colonoscopy: A double-blind, randomized, controlled trial
Primary resultResult — go to the resultMean difference - 1.2% 95% CI −6.5% to 4.0%Authors' conclusion
When comparing the sedation efficacy of ciprofol and propofol, a 0.4 mg kg-1 dose of ciprofol proved to be equal to a 2.0 mg kg-1 dose of propofol, with fewer side effects and greater patient satisfaction during the procedure.
Study context
- Population
- Adults, ASA I to II, BMI 18 to 30 kg m-2, scheduled for colonoscopy
- Comparison
- Ciprofol vs propofol sedation for colonoscopy
- Primary endpoint
- Success rate of colonoscopy
Methodological detailsdouble-blind, single-centre, Single-centre, class A tertiary hospital, November 2021 to November 2022
- Double-blind
- Single-centre
- Single-centre, class A tertiary hospital, November 2021 to November 2022
Primary result
As reported in the abstract
Mean difference
- 1.2%
95% CI −6.5% to 4.0%
P = 0.650
By group
C vs P
mean difference - 1.2% (95% CI −6.5% to 4.0%); P = 0.650
Secondary outcomes
Sedation time
P < 0.001
Fully alert time
P = 0.013
| Outcome | C | P | P value |
|---|---|---|---|
| Patient satisfaction | 10 | 9 | P < 0.001 |
Safety
Respiratory depression
P = 0.021
Hypotension
P = 0.034
| Outcome | C | P | P value |
|---|---|---|---|
| Injection pain | 0 | 40.2% | P < 0.001 |
Original publication
The efficacy and safety of ciprofol and propofol in patients undergoing colonoscopy: A double-blind, randomized, controlled trial. J Clin Anesth. Published 11 April 2024. doi:10.
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