The epidemiology and outcomes of acute kidney injury following orthopaedic procedures: A retrospective cohort study
Authors' conclusion
The incidence of AKI following orthopaedic surgeries is increasing and is associated with adverse outcomes.
Study context
- Population
- Adults ≥18 years undergoing orthopaedic surgery at Landspitali – The National University Hospital, Iceland, 2006–2018, with serum creatinine (SCr) measured adjacent to surgery
- Participants
- 3,208 surgeries
- Exposure
- Acute kidney injury (AKI) vs no AKI after orthopaedic surgery
- AKIn = 222
- Outcome
- Incidence and risk factors of AKI following orthopaedic surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incidence of AKI
AKI
6.9%
222
- Rise in incidence per year
- about 17%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Risk factors for AKIHigher age · per year | OR 1.02 (95% CI 1.01–1.04) | |
| Risk factors for AKIeGFR 30-59 vs eGFR >60 | OR 1.93 (95% CI 1.30–2.81) | |
| Risk factors for AKIeGFR 15-29 vs eGFR >60 | OR 3.24 (95% CI 2.08–4.96) | |
| Risk factors for AKIeGFR <15 vs eGFR >60 | OR 4.08 (95% CI 2.35–6.96) | |
| Long-term mortality | HR 1.41 (95% CI 1.08–1.85) | |
| 0.10.31310Ratio (log scale) |
Risk factors for AKI
| OR (95% CI) | ||
|---|---|---|
| Female sexDecreased odds | 0.73 (0.54–0.98) | |
| 0.512Odds ratio (log scale) |
- Long-term mortality: adjusted for age, sex, preoperative kidney function, emergency surgery, comorbidities and frailty
CKD progression
- Accelerated CKD progression with AKI vs no AKI
Original publication
The epidemiology and outcomes of acute kidney injury following orthopaedic procedures: A retrospective cohort study. Acta Anaesthesiol Scand. Published 19 September 2023. doi:10.
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