The Impact of Cultural and Linguistic Diversity on Sepsis Outcomes in Patients Admitted to ICUs: A Multicenter, Retrospective Cohort Study
Authors' conclusion
Contrary to our hypothesis, in-hospital mortality after ICU admission with sepsis was lower in patients belonging to CaLD backgrounds.
Study context
- Population
- Adults ≥18 years admitted to ICUs in South Western Sydney Local Health District, Australia, with sepsis, 2012–2022
- Participants
- 5,971 sepsis-coded admissions
- Exposure
- Culturally and linguistically diverse (CaLD) vs non-CaLD patients
- CaLDn = 2,792
- non-CaLDn = 3,179reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, matched
- Multicentre
- Matched
Main finding
As reported in the abstract
CaLD
Sixteen percent
435 of 2792
non-CaLD
17%
532 of 3179
CaLD vs non-CaLDRisk ratio (95% CI)P value
12.4% relative risk reduction
0.876(0.763–0.989)
P < 0.001- Adjusted, matched data
- RD −0.022 (95% CI 0.044 to −0.0005); P = 0.05
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (days) (95% CI) | P value |
|---|---|---|
| ICU LOSShorter for CaLD (12.72 hr) | 0.53 (−0.836 to −0.226) | P < 0.001 |
Original publication
The Impact of Cultural and Linguistic Diversity on Sepsis Outcomes in Patients Admitted to ICUs: A Multicenter, Retrospective Cohort Study. Crit Care Med. Published 13 April 2026. doi:10.
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