The Impact of Diuretics on Mortality in Acute Kidney Injury With or Without Fluid Accumulation in Intensive Care—A Retrospective Cohort Study
Main finding · 30-day mortalityResult — go to the resultHazard ratio 1.11 95% CI 0.98–1.26Authors' conclusion
Early diuretic treatment was frequent but not associated with improved survival in the primary analysis.
Study context
- Population
- Adult intensive care unit (ICU) patients with acute kidney injury (AKI) present on or within 48 h of ICU admission, Capital Region of Denmark, 2022–202458% received early diuretics
- Participants
- 4,430 patients
- Exposure
- Early diuretics vs no early diuretics
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological details24-h landmark Cox regression, pre-specified subgroup analyses, post hoc sensitivity analyses
- 24-h landmark Cox regression
- Pre-specified subgroup analyses
- Post hoc sensitivity analyses
Main finding
As reported in the abstract
Hazard ratio
1.11
95% CI 0.98–1.26
P = 0.113
Early diuretics vs No early diuretics
HR 1.11 (95% CI 0.98–1.26); P = 0.113
Observational data: associations, not effects.
Secondary outcomes
30-day mortality, post hoc time-dependent sensitivity analysis
- Diuretic use associated with higher mortality, HR
- 1.27 (95% CI 1.08-1.49, p = 0.004)
- Post hoc
30-day mortality, AKI stage 3 (subgroup)
- Early diuretic use associated with higher risk of mortality, HR
- 1.42 (95% CI 1.16-1.73, p < 0.001)
- Pre-specified subgroup
Fluid accumulation (> 5% ideal body weight)
- Diuretics associated with lower risk of fluid accumulation, OR (p < 0.001)
- 0.58
Major Adverse Kidney Events within 30 days (MAKE30)
- Diuretics associated with higher risk of MAKE30, OR (p = 0.004)
- 1.23
Original publication
The Impact of Diuretics on Mortality in Acute Kidney Injury With or Without Fluid Accumulation in Intensive Care—A Retrospective Cohort Study. Acta Anaesthesiol Scand. Published 29 June 2026. doi:10.
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