The prevalence of sepsis-induced coagulopathy in patients with sepsis – a secondary analysis of two German multicenter randomized controlled trials
Authors' conclusion
SIC is a clinically relevant complication of sepsis. Although it might be less frequent than previously reported, its occurrence is associated with higher morbidity and mortality and should be interpreted as an early warning sign.
Study context
- Population
- Patients fulfilling SEPSIS-3 sepsis criteria in two German multicentre RCTs2 RCTs
- Participants
- 267 vs 1,018
- Comparison
- Sepsis-induced coagulopathy (SIC) vs no SIC
- HYPRESSn = 267
- SISPCTn = 1,018
- Primary endpoint
- Prevalence of sepsis-induced coagulopathy (SIC)
Methodological detailsHYPRESS and SISPCT, multicentre
- HYPRESS and SISPCT
- Multicentre
Primary result
As reported in the abstract
SIC prevalence
Further findings
| Outcome | Values | P value |
|---|---|---|
| 90-day mortality, HYPRESS (no SIC vs SIC) · also higher morbidity | No SIC 13.9% · SIC 26.8% | P = 0.027 |
| 90-day mortality by PSSC, SISPCT | PSSC 0 34.4% · PSSC 1 40.5% · PSSC 2 53.3% | P < 0.001 |
- 90-day mortality, HYPRESS (no SIC vs SIC) — Adjusted logistic regression (age, sex, treatment arm, SIC-adapted SOFA) confirmed negative association of SIC with survival
- p = 0.011
Timing of SIC onset
- In both trials, SIC present at sepsis diagnosis or occurred during the following 4 days
Original publication
The prevalence of sepsis-induced coagulopathy in patients with sepsis – a secondary analysis of two German multicenter randomized controlled trials. Ann Intensive Care. Published 12 January 2023. doi:10.
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