Respiratory failure & ventilation
The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome
Authors' conclusion
Hs-TnT, NT-proBNP and PCT measured on the day of extubation are associated with extubation failure in mechanically ventilated patients with C-ARDS.
Study context
- Population
- Patients with COVID-19 ARDS (C-ARDS) extubated after mechanical ventilation
- Participants
- 297 patients
- Exposure
- Cardiac and inflammatory biomarkers as predictors of extubation failure
- Outcome
- Extubation failure (reintubation or death, regardless of post-extubation respiratory support)
- Follow-up
- Within 7 days after extubation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Extubation failure
- Extubation failure rate
- 21.5%
- NT-proBNP on day of extubation, univariable OR
- 1.24 (95% CI 1.06-1.47)
- High-sensitivity Troponin T (Hs-TnT) on day of extubation, univariable OR
- 1.72 (95% CI 1.37-2.19)
- Procalcitonin (PCT) on day of extubation, univariable OR
- 1.38 (95% CI 1.16-1.65)
- Hs-TnT, aOR after adjustment for age, duration of mechanical ventilation, SOFA (95% CI 1.02-1.90); only independently associated biomarker
- 1.38
Observational data: associations, not effects.
Further findings
Extubation failure by combined Hs-TnT and PCT
- Elevated Hs-TnT (≥ 14 ng/mL) and elevated PCT (≥ 0.25 ng/mL)
- 46%
- Normal Hs-TnT and PCT
- 13%
Original publication
The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome. Ann Intensive Care. Published 9 January 2025. doi:10.
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