Respiratory failure & ventilation
Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study
Main finding · In-hospital mortalityResult — go to the resultAdjusted hazard ratio 1.520 95% CI 1.359–1.700Authors' conclusion
Reintubation was associated with a significant increase in in-hospital and ICU mortality. The highest mortality rates were observed in patients who were reintubated between 72 and 96 h after extubation.
Study context
- Population
- Adults who underwent mechanical ventilation and extubation in intensive care units (ICUs), Japan, April 2015 to March 2021
- Participants
- 48,082 adults · 75 ICUs
- Exposure
- Reintubation vs No reintubation
- Reintubationn = 1,849
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, Japanese Intensive Care PAtient Database
- Multicentre
- Japanese Intensive Care PAtient Database
Main finding
As reported in the abstract
Adjusted hazard ratio
1.520
95% CI 1.359–1.700
Reintubation vs No reintubation
aHR 1.520 (95% CI 1.359–1.700)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values | aHR (95% CI) | |
|---|---|---|---|
| ICU mortality | 1.325 (1.076–1.633) | ||
| In-hospital mortality by reintubation timing (highest at 72-96 h)72-96 h vs Within 24 h | 1.528 (1.062–2.197) | ||
| ICU mortality by reintubation timing (highest at 72-96 h)72-96 h vs Within 24 h | 1.334 (0.756–2.352) | ||
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Values |
|---|---|
| Timing of reintubation after extubation (among reintubated) | Within 24 h 56.1% · 24-48 h 22.6% · 48-72 h 10.7% · 72-96 h 6.0% · 96-120 h 4.6% |
Original publication
Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study. Crit Care. Published 30 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →