Cardiothoracic & vascular anesthesia
Total Intravenous Anesthesia Versus Sevoflurane-Based Inhalation Anesthesia Within an Enhanced Recovery After Cardiac Surgery (ERACS) Protocol
Authors' conclusion
Within a standardized ERACS protocol, TIVA and sevoflurane-based anesthesia were associated with broadly similar short-term outcomes.
Study context
- Population
- Adults undergoing elective or urgent cardiac surgery within an established ERACS program, Heart Center Leipzig, December 2018–July 20211,816 matched
- Participants
- 2,812 adults
- Exposure
- Total intravenous anesthesia (TIVA) vs sevoflurane-based inhalation anesthesia within an ERACS protocol
- TIVAn = 908
- Sevofluranen = 908reference
Methodological detailssingle-center, propensity score-matched
- Single-center
- Propensity score-matched
Further findings
Hospital LOS · slightly shorter with sevoflurane · propensity score-matched
P = 0.015
Postoperative hemodynamic stability
P < 0.001
In-hospital mortality · numerically higher with TIVA
P = 0.142
Median
| Outcome | TIVA | Sevoflurane | Mean difference (minutes) | P value |
|---|---|---|---|---|
| Postoperative pain scoresLower with sevoflurane | 2 (IQR 1–3) | 2 (IQR 1–2) | P < 0.001 | |
| Time to extubationEarlier extubation with TIVA | −4.8 | P = 0.018 |
Original publication
Total Intravenous Anesthesia Versus Sevoflurane-Based Inhalation Anesthesia Within an Enhanced Recovery After Cardiac Surgery (ERACS) Protocol. J Cardiothorac Vasc Anesth. Published 6 June 2026. doi:10.
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