Respiratory failure & ventilation
Trends in characteristics, interventions, and outcomes of hospitalized patients with COVID-19 in Canada: a multicentre prospective cohort study
Authors' conclusion
Among patients hospitalized in Canada with COVID-19, several clinical factors including prior vaccination were associated with lower mortality, but pandemic wave was not.
Study context
- Population
- Adults and children admitted with COVID-19 to 47 Canadian hospitals, 2 January 2020 to 8 February 2022
- Participants
- 5,285 adults · 47 hospitals
- Exposure
- Five pandemic waves
- Outcome
- Hospital mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Intensive care unit (ICU) admission
- Required admission to ICU
- 48% (n = 2,539)
Invasive mechanical ventilation among ICU patients
- Underwent invasive mechanical ventilation
- 60.3% (n = 1,530)
Corticosteroid treatment
- Treated with corticosteroids (most common treatment)
- 48.7%; n = 2,575
- Use of corticosteroids and other evidence-based treatments increased over time
Hospital mortality, ICU and invasive mechanical ventilation subgroups (subgroup)
- Hospital mortality among those admitted to ICU
- 30.2% (n = 766)
- Hospital mortality among those requiring invasive mechanical ventilation
- 37.9% (n = 580)
Vaccination and ICU progression over waves
- Proportion of vaccinated patients increased over time
- Proportion of vaccinated hospitalized patients progressing to ICU fell over waves; unvaccinated did not
Original publication
Trends in characteristics, interventions, and outcomes of hospitalized patients with COVID-19 in Canada: a multicentre prospective cohort study. Can J Anaesth. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →