Unifying Weaning Success Criteria to Bridge the Extracorporeal Membrane Oxygenation Gap: Variations in Determinants Based on Definitions of Successful Weaning
An erratum to this article was published (J Cardiothorac Vasc Anesth, Oct 2026 ↗)
Authors' conclusion
The factors associated with the ECMO gap vary depending on the definition of successful weaning from ECMO. Specifically, advanced age and sepsis (eg, SICS) may hinder long-term recovery and contribute to the ECMO gap.
Study context
- Population
- Adults (≥18 years) who underwent venoarterial extracorporeal membrane oxygenation (VA-ECMO), January 2018–June 2023, tertiary academic centre ICU; patients who died on ECMO excluded110 analysed
- Participants
- 130 adults
- Exposure
- Definition 1 vs Definition 2
- Outcome
- Factors associated with the ECMO gap (multivariate logistic regression)
Methodological detailssingle-centre, Bayesian logistic regression sensitivity analysis
- Single-centre
- Bayesian logistic regression sensitivity analysis
Main finding
As reported in the abstract
- Definition 2: age significantly associated with the ECMO gap
- p = 0.04
- Definition 2: Sepsis-induced cardiogenic shock (SICS) trend toward significance
- p = 0.06
Observational data: associations, not effects.
Further findings
Factors associated with the ECMO gap, Definition 2 (Bayesian logistic regression, sensitivity analysis)
- Age, OR [95% CI]
- 0.08 [0.01-0.16]
- SICS, possible association, OR [95% CI]
- 3.15 [0.26-6.33]
- Wide credible interval suggests caution in interpretation
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Unifying Weaning Success Criteria to Bridge the Extracorporeal Membrane Oxygenation Gap: Variations in Determinants Based on Definitions of Successful Weaning. J Cardiothorac Vasc Anesth. Published 13 May 2025. doi:10.
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