Cardiothoracic & vascular anesthesia
Use of colloids and crystalloids for perioperative clinical infusion management in cardiac surgery patients and postoperative outcomes: a meta-analysis
Authors' conclusion
Both colloids and crystalloids could be used as alternatives for perioperative fluid management after cardiac surgery. The use of crystalloids significantly reduced the postoperative chest tube output, and the need for FFP infusion decreased significantly with the use of isotonic crystalloids or fluid management during the ICU stay. ICU patients in the colloid group had higher urine output 24 h after surgery.
Study context
- Population
- Cardiac surgery patients10 RCTs
- Comparison
- Colloids vs crystalloids for perioperative fluid therapy
- Outcome
- Mortality, transfusion, AKI, AF, postoperative blood loss, hospital LOS, ICU LOS
Methodological detailssubgroup analysis
- Subgroup analysis
Pooled result
As reported in the abstract
- No differences between colloids and crystalloids
Further pooled results
Postoperative chest tube output
- Significantly reduced with crystalloids vs colloids
Fresh frozen plasma (FFP) infused (subgroups: Intensive care unit (ICU) fluid management; isotonic crystalloids)
- Significantly lower with fluid management in the ICU and with isotonic crystalloids vs colloids
Urine volume (subgroup: ICU fluid management) · 24 h after surgery
- Significant increase with colloids
Type of crystalloid, type of colloid, timing of fluid management (subgroups)
- Did not affect most outcomes
Original publication
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