Cardiothoracic & vascular anesthesia
Synthetic colloids as priming fluids in cardiopulmonary bypass and postoperative acute kidney injury: a propensity score-matched study
Main findingResult — go to the resultAdjusted odds ratio 1.785 95% CI 1.262–2.526Authors' conclusion
The use of HES as a priming solution in on-pump cardiac surgery was associated with an increased risk of postoperative AKI compared to gelatin, although it did not affect transfusion requirements.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB), 2018–20221,880 matched pairs analysed
- Participants
- 14,443 adults
- Exposure
- Hydroxyethyl starch (HES) vs succinylated gelatin as CPB priming solution
- HESn = 1,880
- Gelatinn = 1,880reference
- Outcome
- Incidence of postoperative AKI
Methodological detailssingle-centre, propensity-score matched (1:1)
- Single-centre
- Propensity-score matched (1:1)
Main finding
As reported in the abstract
Adjusted odds ratio
1.785
95% CI 1.262–2.526
P = 0.001
By group
HES vs Gelatin
aOR 1.785 (95% CI 1.262–2.526); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
Transfusion requirements
- No significant differences after matching
Postoperative acute kidney injury (AKI) in elderly and female patients (subgroup)
- Effect of HES on AKI greater in elderly and female patients
Original publication
Synthetic colloids as priming fluids in cardiopulmonary bypass and postoperative acute kidney injury: a propensity score-matched study. Perioper Med (Lond). Published 22 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →