Cardiothoracic & vascular anesthesia
Dextran vs. Crystalloid Priming Solution in Cardiac Surgery: A Randomized Trial on Acute Kidney Injury
Primary resultResult — go to the resultRelative risk 1.53 95% CI 1.15–2.06- terminated early (slow enrolment)
- Terminated early due to slow enrolment
Authors' conclusion
In high-risk patients undergoing cardiac surgery with CPB, the use of a dextran-based priming solution was associated with a significantly increased risk of postoperative AKI.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB) with calculated postoperative acute kidney injury (AKI) risk ≥ 50%92 analysed
- Participants
- 101 adults
- Comparison
- Dextran vs crystalloid-based CPB priming solution
- Dextrann = 43
- Controln = 49reference
- Primary endpoint
- Incidence of AKI
- Follow-up
- Within 96 h postoperatively
Methodological detailsdouble-blinded, multicentre
- Double-blinded
- Multicentre
Primary result
As reported in the abstract
Relative risk
1.53
95% CI 1.15–2.06
P = 0.004
By group
Dextran vs Control
RR 1.53 (95% CI 1.15–2.06); P = 0.004
Secondary outcomes
Postoperative RRT
P = 0.66
Intraoperative hemolysis and net fluid balance
- Lower intraoperative hemolysis and more favorable net fluid balance in the dextran group
Safety
Adverse events
- No significant differences between the groups
Original publication
Dextran vs. Crystalloid Priming Solution in Cardiac Surgery: A Randomized Trial on Acute Kidney Injury. Acta Anaesthesiol Scand. Published 27 October 2025. doi:10.
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