Cardiothoracic & vascular anesthesia
Acute kidney injury after lung transplantation, incidence, risk factors, and effects: A Swedish nationwide study
Authors' conclusion
Acute kidney injury is common after lung transplantation and affects clinical outcomes negatively.
Study context
- Population
- Lung-transplanted patients in Sweden, 2011–2020
- Participants
- 568 patients
- Outcome
- Incidence of early postoperative AKI (KDIGO criteria)
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Incidence of acute kidney injury (AKI) (any grade)
42%
Observational data: associations, not effects.
Further findings
Preoperative factors independently associated with increased AKI incidence
| OR (95% CI) | ||
|---|---|---|
| Higher BMI | 1.07 (1.02–1.12) | |
| Longer time on transplantation waiting list | 1.05 (1.01–1.09) | |
| Re-transplantation | 2.24 (1.05–4.80) | |
| Moderate to severe tricuspid regurgitation | 2.61 (1.36–5.03) | |
| 0.20.5125Odds ratio (log scale) |
Intraoperative factors independently associated with increased AKI incidence
| OR (CI) | ||
|---|---|---|
| Use of CPB | 2.70 (1.57–4.63) | |
| 0.20.5125Odds ratio (log scale) |
Higher diuresis and AKI incidence
| OR (95% CI) | ||
|---|---|---|
| Higher diuresisAssociated with less AKI | 0.70 (0.58–0.85) | |
| 0.512Odds ratio (log scale) |
Time to extubation, AKI vs no AKI
ICU LOS, AKI vs no AKI
| Outcome | OR (CI) | |
|---|---|---|
| Primary graft dysfunction and 30-day mortality, AKI vs no AKIPrimary graft dysfunction | 2.33 (1.66–3.29) | |
| Primary graft dysfunction and 30-day mortality, AKI vs no AKI | 10.8 (3.0–69) | |
| 0.050.21520Odds ratio (log scale) |
RRT use
- RRT used
- 5%
Intraoperative factors independently associated with increased AKI incidence
- Increasing number of transfused RBC units associated with increased AKI incidence
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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