Cardiothoracic & vascular anesthesia
Analysis of Risk Factors for Heparin Resistance During Cardiac Surgery: Does Antithrombin Deficiency Cause Heparin Resistance?
Main finding · Preoperative antithrombin activity and HRResult — go to the resultOdds ratio 1.00 95% CI 0.98–1.01Authors' conclusion
An active infection and aortic surgery were identified as risk factors for HR. Antithrombin deficiency was not a significant risk factor for HR in cardiovascular surgery
Study context
- Population
- Patients undergoing cardiovascular (valve and aortic) surgery with cardiopulmonary bypass (CPB), excluding emergency aortic dissection, at a tertiary referral hospital
- Participants
- 605 patients
- Exposure
- HR vs non-HR during CPB
- HRn = 164
- Non-HRn = 441reference
- Outcome
- Preoperative antithrombin activity and HR
Methodological detailsdata collected prospectively, single-centre
- Data collected prospectively
- Single-centre
Main finding
As reported in the abstract
Odds ratio
1.00
95% CI 0.98–1.01
P = 0.786
HR vs non-HR during CPB
OR 1.00 (95% CI 0.98–1.01); P = 0.786
Observational data: associations, not effects.
Further findings
Active infection at surgery and HR
| OR (95% CI) | P value | ||
|---|---|---|---|
| Active infectionMultivariable analysis | 2.30 (1.25–4.21) | P = 0.007 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Isolated aortic surgery and HRIsolated aortic surgery vs Isolated valve surgery | 1.74 (1.12–2.71) | P = 0.014 | |
| 0.20.5125Odds ratio (log scale) |
Safety
Major composite complications
P = 0.025
Major composite complications
- No clear differences in the incidence of individual complications
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Analysis of Risk Factors for Heparin Resistance During Cardiac Surgery: Does Antithrombin Deficiency Cause Heparin Resistance? J Cardiothorac Vasc Anesth. Published 9 April 2025. doi:10.
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