Cardiothoracic & vascular anesthesia
Assessment of a Quantra-Guided Hemostatic Algorithm in High-Bleeding-Risk Cardiac Surgery
Authors' conclusion
Implementation of a Quantra-based hemostatic algorithm was associated with a decrease in transfusion requirement and major bleeding after high-bleeding-risk cardiac surgery.
Study context
- Population
- Patients facing high-bleeding-risk cardiac surgery with CPB, university hospitalpropensity-score matched
- Participants
- 66 vs 117
- Comparison
- Quantra-guided vs laboratory-guided hemostatic algorithm
- Quantran = 66
- Controln = 117reference
- Outcome
- Number of RBC units transfused
- Follow-up
- Day 1 after surgery
Methodological detailssingle-centre, propensity-score matched
- Single-centre
- Propensity-score matched
Main finding
As reported in the abstract
RBC units transfused · day 1
P = 0.016
Further findings
Red blood cell (RBC) units transfused, intraoperative
- Fewer in Quantra vs control, median [IQR] (Quantra v control)
- 2 [0-3] v 3 [1-5], p = 0.005
Fresh frozen plasma units, intraoperative
- Less in Quantra vs control, median [IQR] (Quantra v control)
- 0 [0-3] v 3[2-5], p < 0.0001
Platelet units, intraoperative
- Fewer in Quantra vs control, median [IQR] (Quantra v control)
- 7.5 [0-10] v 8.2 [6.3-11.7], p = 0.014
Intraoperative RBC transfusion rate
- Reduced in Quantra vs control (Quantra v control)
- 64% v 78%, p = 0.05
Intraoperative plasma transfusion rate
- Reduced in Quantra vs control (Quantra v control)
- 41% v 85%, p < 0.001
Intraoperative platelet transfusion rate
- Reduced in Quantra vs control (Quantra v control)
- 55% v 82%, p = 0.001
RBC and plasma transfusions · Days 1, 2 and 7
- Reduced on days 1, 2, and 7
Major bleeding · Day 1
- Incidence reduced in Quantra vs control (Quantra v control)
- 36% v 56%, p = 0.014
Major bleeding (multivariate analysis)
- Quantra-guided algorithm independently associated with reductions in major bleeding
Original publication
Assessment of a Quantra-Guided Hemostatic Algorithm in High-Bleeding-Risk Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 3 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →