Cardiothoracic & vascular anesthesia
Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Trial
Primary result · Self-reported cognitive function (PROMIS Applied Cognition-Abilities)Result — go to the resultMD −2.64 95% CI −5.25 to −0.04Authors' conclusion
In this cohort of older patients undergoing cardiac surgery, in-hospital delirium was associated with SCD up to 180 days after surgery.
Study context
- Population
- Patients aged 60 years or older undergoing cardiac surgery with CPB at a tertiary medical center in Boston, Massachusetts
- Participants
- 337 patients
- Comparison
- Postoperative delirium vs no delirium
- Deliriumn = 39
Methodological detailsrandomized, placebo-controlled, parallel-arm, superiority, Patients recruited March 2017 to February 2022; analysed February 2023
- Randomized
- Placebo-controlled
- Parallel-arm
- Superiority
- Patients recruited March 2017 to February 2022; analysed February 2023
Primary result
As reported in the abstract
Self-reported cognitive function (Patient-Reported Outcomes Measurement Information System (PROMIS) Applied Cognition-Abilities) · up to 180 days after surgery
MD
−2.64
95% CI −5.25 to −0.04
P = 0.047
Delirium vs Nondelirious
MD −2.64 (95% CI −5.25 to −0.04); P = 0.047
Further findings
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Objective cognition (t-MoCA) | −0.77 (−1.49 to −0.04) | P = 0.04 | |
| −2−101Difference (linear scale) |
- Postoperative delirium incidence · within 3 days
- 11.6% · 39
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Trial. J Cardiothorac Vasc Anesth. Published 30 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →