Cardiothoracic & vascular anesthesia
Association of Oxygenation Targets and Mortality in Critical Care Patients Following Cardiac Surgery: A Retrospective Cohort Study
Authors' conclusion
The relationship between PaO2 level and all-cause in-hospital mortality followed a J-shaped curve among patients following cardiac surgery. When PaO2 > 196.1mmHg, higher levels of PaO2 within 24 hours after cardiac surgery were associated with an increased risk of hospital mortality.
Study context
- Population
- Patients who underwent cardiac surgery under extracorporeal circulation, admitted to intensive care units (ICUs) at Beth Israel Deaconess Medical Center (MIMIC-III)
- Exposure
- Four PaO2 categories within 24 h of ICU admission after cardiac surgery
- Outcome
- In-hospital all-cause mortality
Methodological detailsMIMIC-III database, restricted cubic spline regression
- MIMIC-III database
- Restricted cubic spline regression
Main finding
As reported in the abstract
In-hospital mortality vs PaO2
Nonlinear (J-shaped) relationship between PaO2 and in-hospital mortality
Poverall = 0.004; Pnonlinearity = 0.012
In-hospital deaths
73
1.4%
Observational data: associations, not effects.
Further findings
All-cause mortality during follow-up · 1 year
- Deaths during 1-year follow-up
- 296 (5.5%)
- Deaths within 30 days
- 83 (1.6%)
- Deaths within 90 days
- 167 (3.1%)
Subgroup and sensitivity analyses
- Consistent with the primary analysis
Original publication
Association of Oxygenation Targets and Mortality in Critical Care Patients Following Cardiac Surgery: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 3 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →