Cardiothoracic & vascular anesthesia
Intraoperative respiratory exchange ratio to predict complications after cardiopulmonary bypass surgery: a retrospective cohort study
Authors' conclusion
While RER showed a modest relationship with hyperlactatemia, its utility as a predictor of postoperative complications appears limited in real-world data.
Study context
- Population
- Adults undergoing cardiac surgery with CPB at Beth Israel Deaconess Medical Center, Boston, US, 2008–2020324,646 respiratory exchange ratio (RER) calculations
- Participants
- 4,058 adults
- Outcome
- 7-day major postoperative complications (European Perioperative Clinical Outcome Definitions), association with median intraoperative RER
- Follow-up
- 7 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association of median RER with 7-day postoperative complications
Adjusted odds ratio (95% CI)P value
RER before bypass
1.02(0.95–1.10)
P = 0.55RER after bypass
1.03(0.95–1.13)
P = 0.46- Patients with 7-day postoperative complications
- 1,745 (43.0%)
Observational data: associations, not effects.
Further findings
Lactate > 2 mmol/l, RER within 10 min prior to lactate testing
| aOR (95% CI) | P value | ||
|---|---|---|---|
| RER | 1.11 (1.01–1.23) | P = 0.031 | |
| 0.512Adjusted odds ratio (log scale) |
Median
| Outcome | Before bypass | After bypass |
|---|---|---|
| Median RER | 0.64 (IQR 0.48–0.92) | 0.65 (IQR 0.48–0.97) |
Original publication
Intraoperative respiratory exchange ratio to predict complications after cardiopulmonary bypass surgery: a retrospective cohort study. J Clin Monit Comput. Published 15 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →