Cardiothoracic & vascular anesthesia
Combined Platelet and Red Blood Cell Recovery during On-pump Cardiac Surgery Using same™ by i-SEP Autotransfusion Device: A First-in-human Noncomparative Study (i-TRANSEP Study)
Authors' conclusion
In this first-in-human study, the same™ device was able to simultaneously recover and wash both platelets and red blood cells.
Study context
- Population
- Adults undergoing on-pump elective cardiac surgery
- Participants
- 50 adults
- Outcome
- Composite of:
- Cell recovery performance (RBC recovery, posttreatment hematocrit)
- Biologic safety (heparin and free hemoglobin removal ratios)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
RBC recovery per cycle, median (IQR 80.8 to 91.6)
86.1%
Posttreatment hematocrit (39.7 to 44.2)
41.8%
Heparin removal ratio (98.2 to 99.7)
98.9%
Free hemoglobin removal ratio (92.7 to 96.6)
94.6%
Secondary outcomes
Platelet recovery
- Median platelet recovery (44.2 to 60.1)
- 52.4%
- Posttreatment platelet concentration, · 109/l (93 to 146)
- 116
Platelet activation state and function (flow cytometry)
- Unaltered by the device
Safety
Adverse device effects · up to 30 days after surgery
- No adverse device effect reported
Original publication
Combined Platelet and Red Blood Cell Recovery during On-pump Cardiac Surgery Using same™ by i-SEP Autotransfusion Device: A First-in-human Noncomparative Study (i-TRANSEP Study). Anesthesiology. Published 9 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →