Cardiothoracic & vascular anesthesia
Derivation and Validation of Clinical Phenotypes of the Cardiopulmonary Bypass–Induced Inflammatory Response
Authors' conclusion
Deriving clinical phenotypes that correlate with response biomarkers and outcomes represents an initial step toward a precision medicine approach for the management of CPB-induced inflammatory response
Study context
- Population
- Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), Cleveland Clinic registry, January 2010 to March 2020 (excluding emergent, off-pump, transplantation, descending thoracoabdominal aortic surgery, planned ventricular assist device)of 36,865 eligible cases
- Participants
- 25,613 patients
- Exposure
- Clinical phenotypes α vs β vs γ of the CPB-induced inflammatory response
- αn = 6,157
- βn = 10,572
- γn = 8,884
- Outcome
- Derived clinical phenotypes
Methodological detailssingle-centre, K-means-based consensus clustering
- Single-centre
- K-means-based consensus clustering
Main finding
As reported in the abstract
Phenotype α share of cohort
24%
Phenotype β share of cohort
41%
Phenotype γ share of cohort
35%
Observational data: associations, not effects.
Further findings
Hospital LOS — α vs β
absolute standardized difference 1.15
| Outcome | Absolute standardized difference |
|---|---|
| Hospital LOSα vs γ | 1.08 |
Kidney failure and mortality
- More kidney failure and higher mortality with phenotype α
Inflammatory (IL-6, IL-8) and kidney injury (urine NGAL, IL-18) biomarkers · immediately after surgery
- Higher with α phenotype vs β and γ
Original publication
Derivation and Validation of Clinical Phenotypes of the Cardiopulmonary Bypass–Induced Inflammatory Response. Anesth Analg. Published 4 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →