Cardiothoracic & vascular anesthesia
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Pooled result · Low certaintyResult — go to the resultOdds ratio 0.42 95% CI 0.18–0.95Authors' conclusion
Dexmedetomidine administration during thoracic surgery may potentially reduce the risk of postoperative atelectasis and hypoxemia.
Study context
- Population
- Patients undergoing thoracic surgery under one-lung ventilation (OLV)12 RCTs
- Participants
- 365 vs 359
- Comparison
- Dexmedetomidine vs placebo during thoracic surgery
- Dexmedetomidinen = 365
- Placebon = 359reference
- Outcome
- Atelectasis
- Follow-up
- Within 7 days after surgery
Methodological detailsrandom effects models
- Random effects models
Pooled result
Low certainty
Odds ratio
0.42
95% CI 0.18–0.95
P = 0.04
By group
Dexmedetomidine vs Placebo
OR 0.42 (95% CI 0.18–0.95); P = 0.04
As reported in the abstract
Further pooled results
| Outcome | Dexmedetomidine | Placebo | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative hypoxemiaModerate certainty | 3.4% | 11.7% | 0.26 (0.10–0.68) | P = 0.01 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Mean difference (mL/cmH2O) (95% CI) | |
|---|---|---|
| Intraoperative respiratory compliance (Cdyn) | 4.42 (3.13–5.72) | |
| −50510Difference, mL/cmH2O (linear scale) |
| Outcome | Mean difference (L) (95% CI) | |
|---|---|---|
| Postoperative FEV1 | 0.27 (0.12–0.41) | |
| −0.200.20.40.6Difference, L (linear scale) |
Postoperative pneumonia
- OR
- 0.57 (95%CI 0.25-1.26, P = 0.17)
- Incidence comparable between groups (3.2% vs 5.8%)
- Moderate certainty
Postoperative acute respiratory distress syndrome (ARDS)
- OR
- 0.39 (95%CI 0.07-2.08, P = 0.27)
- Incidence comparable between groups (0.9% vs 3.5%)
- Moderate certainty
Original publication
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. J Clin Anesth. Published 20 November 2023. doi:10.
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