Cardiothoracic & vascular anesthesia
Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomised controlled trial
Primary result · Major complications (Clavien-Dindo Grade ≥III)Result — go to the resultOdds ratio 0.44 95% CI 0.22–0.88Authors' conclusion
Intraoperative lidocaine infusion administered either intravenously or through paravertebral catheter reduces the incidence and severity of complications after lung resection surgery compared with remifentanil.
Study context
- Population
- Patients undergoing lung resection (video-assisted thoracoscopy)
- Participants
- 154 patients
- Comparison
- Intraoperative i.v. or paravertebral lidocaine vs remifentanil
- Paravertebral lidocainen = 49
- i.v. lidocainen = 54
- Remifentaniln = 51reference
- Primary endpoint
- Proportion with all-cause complications (Clavien-Dindo classification)
Methodological detailssingle-centre
- Single-centre
Primary result
Major complications (Clavien-Dindo Grade ≥III)
Odds ratio
0.44
95% CI 0.22–0.88
Events by treatment group
Lidocaine (i.v. or paravertebral) vs Remifentanil
OR 0.44 (95% CI 0.22–0.88)
As reported in the abstract
Further findings
| Outcome | Remifentanil | OR (95% CI) | P value | |
|---|---|---|---|---|
| Pulmonary complicationsLidocaine (i.v. or paravertebral) vs Remifentanil | 45.1% | 0.35 (0.17–0.72) | P = 0.004 | |
| 0.10.31310Odds ratio (log scale) |
- Pulmonary complications: Lidocaine (i.v. or paravertebral) 22.3%
Cytokine levels after OLV
- Lower with lidocaine treatment
Original publication
Effect of intraoperative paravertebral or intravenous lidocaine infusion on postoperative complications and inflammation after lung resection surgery: a randomised controlled trial. Br J Anaesth. Published 1 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →