Cardiothoracic & vascular anesthesia
Effect of Dexmedetomidine on Endothelial Glycocalyx in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass
Authors' conclusion
Dexmedetomidine preserves endothelial glycocalyx integrity and attenuates systemic inflammation in CPB patients.
Study context
- Population
- Patients undergoing elective valvular cardiac surgery with cardiopulmonary bypass (CPB)
- Participants
- 58 patients
- Comparison
- Dexmedetomidine vs saline infusion
- Dexmedetomidinen = 29
- Salinen = 29reference
- Primary endpoint
- Plasma syndecan-1 concentration
Methodological detailssingle-centre, June 2022 to December 2022
- Single-centre
- June 2022 to December 2022
Primary result
As reported in the abstract
Glycocalyx shedding
- Significantly less glycocalyx shedding with dexmedetomidine vs controls, persisting throughout CPB and recovery
Secondary outcomes
TNF-α levels · T2-T3
- Significantly lower with dexmedetomidine
Lactate levels · aortic unclamping
- Reduced with dexmedetomidine
Original publication
Effect of Dexmedetomidine on Endothelial Glycocalyx in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. Published 1 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →