Cardiothoracic & vascular anesthesia
Efficacy of intravenous iron supplementation in reducing transfusion risk following cardiac surgery: an updated meta-analysis of randomised controlled trials
Pooled resultResult — go to the resultRelative risk 0.77 95% CI 0.65–0.91Authors' conclusion
Intravenous iron supplementation can reduce RBC transfusion risk and improve postoperative haemoglobin level and iron status after cardiac surgery
Study context
- Population
- Adults undergoing cardiac surgery
- Participants
- 2,043 adults · 14 RCTs
- Comparison
- IV iron supplementation vs controls
- Outcome
- Incidence of red blood cell (RBC) transfusion
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.77
95% CI 0.65–0.91
P = 0.002
Intravenous iron supplementation vs Controls
RR 0.77 (95% CI 0.65–0.91); P = 0.002
Further pooled results
| Outcome | Mean difference (g dl-1) (95% CI) | |
|---|---|---|
| Haemoglobin, POD 4-10 · postoperative days 4-10n=1989 | 0.17 (0.06–0.29) | |
| −0.200.20.4Difference, g dl-1 (linear scale) |
| Outcome | Mean difference (g/dl-1) (95% CI) | |
|---|---|---|
| Haemoglobin, >21 daysn=1008 | 0.66 (0.36–0.95) | |
| −0.500.51Difference, g/dl-1 (linear scale) |
Postoperative iron status
- Improved with IV iron, particularly on POD 4-10
Other outcomes incl. mortality
- No significant differences
Original publication
Efficacy of intravenous iron supplementation in reducing transfusion risk following cardiac surgery: an updated meta-analysis of randomised controlled trials. Br J Anaesth. Published 27 September 2024. doi:10.
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