Cardiothoracic & vascular anaesthesia
Oxygen delivery during cardiopulmonary bypass and postoperative mortality: A retrospective cohort study
Main finding · 30-day mortalityResult — go to the resultAdjusted odds ratio 1.16 95% CI 1.09–1.23Authors' conclusion
Patients receiving lower intraoperative DO2i during cardiopulmonary bypass had a higher risk of postoperative mortality, AKI, and prolonged recovery.
Study context
- Population
- Adults undergoing cardiac surgery with CPB at a tertiary centre, 2018–2024
- Participants
- 4,358 adults
- Exposure
- Lower vs higher time-weighted average indexed oxygen delivery during CPB
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailssingle tertiary centre, multivariable-adjusted
- Single tertiary centre
- Multivariable-adjusted
Main finding
As reported in the abstract
Adjusted odds ratio
1.16
95% CI 1.09–1.23
P < 0.001
By group
Each 10 ml · min −1 · m −2 decrease in DO2i
aOR 1.16 (95% CI 1.09–1.23); P < 0.001
Each 10 ml · min −1 · m, as printed
- Overall 30-day deaths
- 75 (1.7%)
Observational data: associations, not effects.
Secondary outcomes
Acute kidney injury (AKI)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Lower DO2i | 1.05 (1.03–1.07) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Intensive care unit (ICU) LOS
| Adjusted IRR (95% CI) | P value | ||
|---|---|---|---|
| Lower DO2i | 1.02 (1.01–1.03) | P < 0.001 | |
| 0.512Adjusted incidence rate ratio (log scale) |
Hospital LOS
| Adjusted IRR (95% CI) | P value | ||
|---|---|---|---|
| Lower DO2i | 1.01 (1.01–1.02) | P < 0.001 | |
| 0.512Adjusted incidence rate ratio (log scale) |
Stroke
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Lower DO2iNot associated | 1.00 (0.95–1.06) | P = 0.877 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Oxygen delivery during cardiopulmonary bypass and postoperative mortality: A retrospective cohort study. Anesthesiology. Published 28 September 2026. doi:10.
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