Cardiothoracic & vascular anesthesia
Perioperative Renal Perfusion Pressure Deficits and Risk of Acute Kidney Injury in Cardiac Surgery: A Pilot Study Using Right Heart Catheterization (PRO-AKI)
Authors' conclusion
Greater postoperative decreases in RPP and MAP from preoperative baseline were independently associated with increased AKI risk after cardiac surgery.
Study context
- Population
- Patients undergoing cardiac surgery with CPB, single academic medical center, July 2018 to March 2024
- Participants
- 486 patients
- Comparison
- Acute kidney injury (AKI) vs Without AKI
- AKIn = 70
- Without AKIn = 416reference
- Outcome
- AKI progression (Kidney Disease: Improving Global Outcomes score)
Methodological detailspilot, single-centre
- Pilot
- Single-centre
Main finding
As reported in the abstract
AKI incidence and postoperative RPP and MAP percent deficits · postoperative days 0 to 4
Odds ratio (95% CI)P value
10% decrease in average RPP
1.46(1.03–2.10)
P < 0.03610% decrease in average MAP
1.42(1.16–1.75)
P < 0.001Observational data: associations, not effects.
Original publication
Perioperative Renal Perfusion Pressure Deficits and Risk of Acute Kidney Injury in Cardiac Surgery: A Pilot Study Using Right Heart Catheterization (PRO-AKI). J Cardiothorac Vasc Anesth. Published 28 August 2025. doi:10.
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