Cardiothoracic & vascular anesthesia
Phase Angle as a Reliable Biomarker of Frailty to Predict Postoperative Outcomes in Patients Undergoing Off-Pump Coronary Artery Grafting: A Prospective Observational Study
Authors' conclusion
Low PA as an indicator of frailty is associated with adverse postoperative outcomes after OPCAB.
Study context
- Population
- Adults undergoing off-pump CABG (OPCAB), May 2019 to October 2020
- Participants
- 229 adults
- Exposure
- Composite adverse outcome vs no complications, by phase angle
- Outcome
- Composite adverse outcome:
- Death
- MI
- Revascularization
- New-onset AF
- AKI
- Stroke
- PPCs
- Wound complications
- Sepsis
- Reoperation
- Delirium
- Follow-up
- During hospitalization and over the following year
Methodological detailssingle-centre, high-volume, phase angle (PA) by bioelectrical impedance analysis (Inbody S10) before surgery, immediately postoperatively and on POD1; frailty index and nutritional assessments before surgery
- Single-centre
- High-volume
- PA by bioelectrical impedance analysis (Inbody S10) before surgery, immediately postoperatively and on POD1; frailty index and nutritional assessments before surgery
Main finding
As reported in the abstract
Preoperative PA (PApre)
Composite adverse outcome
5.4
± 0.9
No complications
6.0
± 0.9
P < 0.001
Observational data: associations, not effects.
Further findings
PApre and in-hospital complications
| OR (95% CI) | P value | ||
|---|---|---|---|
| PApre | 0.435 (0.314–0.604) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
PApre and 1-year complications
| OR (95% CI) | P value | ||
|---|---|---|---|
| PApre | 0.459 (0.330–0.638) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
PAPOD1 and in-hospital complications
| OR (95% CI) | ||
|---|---|---|
| PAPOD1 | 0.400 (0.277–0.576) | |
| 0.20.5125Odds ratio (log scale) |
PAPOD1 and 1-year complications
| OR (95% CI) | P value | ||
|---|---|---|---|
| PAPOD1 | 0.429 (0.298–0.619) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Values |
|---|---|
| PApre cut-off for predicting in-hospital complications | PApre cut-off 6.0 · AUC 0.691 [0.623-0.758] |
- PApre cut-off for predicting in-hospital complications: p < 0.001
DAOH until 1 year
- PApre significantly associated with DAOH until 1 year
Original publication
Phase Angle as a Reliable Biomarker of Frailty to Predict Postoperative Outcomes in Patients Undergoing Off-Pump Coronary Artery Grafting: A Prospective Observational Study. J Cardiothorac Vasc Anesth. Published 18 September 2023. doi:10.
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