Cardiothoracic & vascular anesthesia
Platelet Function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine
Authors' conclusion
During cardiac surgery with moderate CPB times, platelet function was not impaired, and no consumption of circulating platelets could be detected. Administration of protamine transiently affected platelet function.
Study context
- Population
- Patients scheduled for CABG with cardiopulmonary bypass (CPB)
- Participants
- 39 patients
- Outcome
- Changes in platelet function (impedance aggregometry, flow cytometry) and number during CPB
Methodological detailssingle-centre, Measurements at 6 time points: baseline before anaesthesia, end of CPB, after protamine, intensive care unit (ICU) arrival, 3 h after ICU arrival, morning after surgery
- Single-centre
- Measurements at 6 time points: baseline before anaesthesia, end of CPB, after protamine, ICU arrival, 3 h after ICU arrival, morning after surgery
Main finding
As reported in the abstract
Platelet function and count during CPB
- Circulating platelets corrected for dilution, before CPB, mean ± SD
- 1.73 ± 0.42 × 109/g
- Circulating platelets corrected for dilution, end of CPB, mean ± SD
- 1.91 ± 0.51 × 109/g
- Increase in dilution-corrected platelet count during CPB
- p < 0.001
- CPB duration
- 85.0 ± 21 min
Observational data: associations, not effects.
Further findings
Platelet function after protamine · after protamine administration
- Decrease in platelet function with impedance aggregometry and some flow cytometry activation markers
- Platelet function restored 3 h after ICU arrival
Original publication
Platelet Function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine. J Cardiothorac Vasc Anesth. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →