Cardiothoracic & vascular anesthesia
Propofol Versus Remimazolam on Cognitive Function, Hemodynamics, and Oxygenation During One-Lung Ventilation in Older Patients Undergoing Pulmonary Lobectomy: A Randomized Controlled Trial
Authors' conclusion
The results showed that remimazolam (versus propofol) may lessen the degree of short-term postoperative cognitive dysfunction measured by standard neuropsychological tests, better optimize intraoperative hemodynamics, and lead to improved oxygenation during OLV.
Study context
- Population
- Older patients (aged ≥65 years) with lung cancer undergoing lobectomy with one-lung ventilation (OLV)
- Participants
- 84 patients
- Comparison
- Remimazolam vs propofol for anaesthesia induction and maintenance
Methodological detailsprospective, double-blind, single university hospital
- Prospective
- Double-blind
- Single university hospital
Primary result
As reported in the abstract
Postoperative cognitive function (VFT, DSST, immediate and short-delayed recall AVLT-H scores) · day 7 after surgery
- Verbal Fluency Test (VFT), Digit Symbol Switching Test (DSST), immediate recall Auditory Verbal Learning Test-Huashan (AVLT-H) and short-delayed recall AVLT-H scores significantly higher in R than P
- p < 0.05
Further findings
Systolic blood pressure (SBP) and mean arterial pressure (MAP) · T2 to T5
- SBP and MAP significantly higher in R than P
Phenylephrine dose
- Remimazolam significantly reduced phenylephrine dose
- P < 0.05
PaO2, oxygenation index (OI) and Qs/Qt · T4 (60 minutes after OLV)
- PaO2 and OI significantly higher and Qs/Qt significantly lower in R than P
S-100β levels · T5 (end of surgery)
- S-100β significantly lower in R than P
- P < 0.05
Safety
Hypotension
P = 0.004
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Propofol Versus Remimazolam on Cognitive Function, Hemodynamics, and Oxygenation During One-Lung Ventilation in Older Patients Undergoing Pulmonary Lobectomy: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 19 June 2023. doi:10.
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