Cardiothoracic & vascular anaesthesia
Respiratory complications after oesophagectomy using volatile or intravenous anaesthesia
Main finding · Respiratory complicationsResult — go to the resultOdds ratio 1.13 95% CI 1.03–1.24Authors' conclusion
Sevoflurane and propofol anaesthesia for oesophagectomy were associated with worse respiratory outcomes compared with desflurane anaesthesia.
Study context
- Population
- Patients undergoing oesophagectomy for cancer, nationwide Japanese inpatient database, April 2012-March 2022
- Participants
- 21,080 patients
- Exposure
- Sevoflurane or propofol vs desflurane anaesthesia
- Desfluranen = 7,823reference
- Sevofluranen = 8,932
- Propofoln = 4,325
- Outcome
- Respiratory complications
Methodological detailspropensity score matching weight analysis, nationwide inpatient database, sensitivity analyses (multivariable logistic regression, instrumental variable)
- Propensity score matching weight analysis
- Nationwide inpatient database
- Sensitivity analyses (multivariable logistic regression, instrumental variable)
Main finding
As reported in the abstract
Odds ratio
1.13
95% CI 1.03–1.24
Sevoflurane vs Desflurane
OR 1.13 (95% CI 1.03–1.24)
- Respiratory complications, all included patients
- 3399 (16.1%)
Observational data: associations, not effects.
Further findings
| Outcome | Desflurane | Sevoflurane | Propofol | OR (95% CI) | |
|---|---|---|---|---|---|
| In-hospital mortalitySevoflurane vs Desflurane · matching weight analysis | 1.2% | 1.6% | 1.8% | 1.30 (0.98–1.73) | |
| 0.512Odds ratio (log scale) |
Ventilatory failure
- Ventilatory failure, all included patients
- 960 (4.6%)
- Matching weight analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Respiratory complications after oesophagectomy using volatile or intravenous anaesthesia. Br J Surg. Published 1 April 2025. doi:10.
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