Cardiothoracic & vascular anesthesia
The Association of Oxygen Delivery and Transfusion on Cardiopulmonary Bypass with Acute Kidney Injury
Authors' conclusion
We found a nonlinear relationship between oxygen delivery and AKI. We found no level of oxygen delivery at which transfusion was associated with a decreased risk of AKI.
Study context
- Population
- Patients undergoing cardiac surgery with continuous oxygen delivery monitoring during CPB
- Participants
- 4,203 patients
- Exposure
- Oxygen delivery on CPB and transfusion vs no transfusion
- Outcome
- AKI
- Follow-up
- 7 days
Methodological detailslogistic regression, exact-matched subgroup analysis, propensity score adjustment
- Logistic regression
- Exact-matched subgroup analysis
- Propensity score adjustment
Main finding
As reported in the abstract
AKI within 7 days
Odds ratio (95% CI)P value
Lower mean oxygen delivery
0.968(0.949–0.988)
P = 0.002Transfusions
1.442(1.077–1.932)
P = 0.014Observational data: associations, not effects.
Further findings
AKI, matched subgroup analysis (subgroup) · unadjusted
P < 0.001
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| AKI, matched subgroup analysis (subgroup)After propensity score adjustment; nonsignificant | 1.181 (0.796–1.752) | P = 0.406 | |
| 0.512Odds ratio (log scale) |
- Acute kidney injury (AKI), matched subgroup analysis (subgroup): exact matching on cumulative oxygen deficit and time on bypass
Original publication
The Association of Oxygen Delivery and Transfusion on Cardiopulmonary Bypass with Acute Kidney Injury. J Cardiothorac Vasc Anesth. Published 18 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →