Cardiothoracic & vascular anesthesia
Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study
Authors' conclusion
UTI administration may mitigate glycocalyx degradation, potentially lowering the risk of POD in cardiac surgery patients
Study context
- Population
- Adult cardiac surgery patientsplus prospective cohort of 241
- Participants
- 6,522 patients
- Exposure
- Intraoperative ulinastatin (UTI) vs no UTI
- Outcome
- POD
Methodological detailsmulticentre, propensity score matching, multivariate logistic regression
- Multicentre
- Propensity score matching
- Multivariate logistic regression
Main finding
As reported in the abstract
POD (retrospective cohort)
- Intraoperative UTI associated with significantly lower risk of postoperative delirium (POD) (univariate and multivariate logistic regression; confirmed by propensity score matching)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| POD (prospective observational cohort) | 0.392 (0.157–0.977) | P = 0.044 | |
| 0.10.31310Adjusted odds ratio (log scale) |
- POD (prospective observational cohort): 241 patients
Glycocalyx degradation (in vitro)
- UTI mitigated glycocalyx degradation
Original publication
Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study. Crit Care. Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →