Cardiothoracic & vascular anesthesia
Unresponsive Low Mixed Venous Oxygen Saturation During Early Intensive Care Unit Stay is Associated With Increased Risk of Organ Dysfunction After Cardiac Surgery: A Single-Center Retrospective Study
Authors' conclusion
Patients with SvO2 <60% at ICU admission and 4 hours later had the greatest risk of postoperative MODS.
Study context
- Population
- Adults undergoing cardiac surgery at a university hospital, 2007 to 20204 SvO2 groups
- Participants
- 6,282 adults
- Exposure
- SvO2 groups at intensive care unit (ICU) admission and 4 h later
- Outcome
- Organ dysfunction in the sustained low SvO2 group (adjusted logistic regression)
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Sustained low SvO2Odds ratio (95% CI)
MODS
4.23(3.41–5.25)
RRT
4.97(3.28–7.52)
Time on a ventilator
2.34(2.17–2.52)
Vasoactive-inotropic score >30
3.62(2.96–4.43)
Observational data: associations, not effects.
Further findings
Crude mortality (cohort) · 1 year
- Crude mortality
- 4.3%
Multiple organ dysfunction syndrome (MODS) in early postoperative phase (cohort)
- MODS present
- 33.0%
Response to GDT among 931 with low SvO2 on admission · 4 hours
- Responded (SvO2 >60%)
- 43%
- Low SvO2 sustained
- 57%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Unresponsive Low Mixed Venous Oxygen Saturation During Early Intensive Care Unit Stay is Associated With Increased Risk of Organ Dysfunction After Cardiac Surgery: A Single-Center Retrospective Study. J Cardiothorac Vasc Anesth. Published 17 November 2023. doi:10.
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