Cardiothoracic & vascular anesthesia
Urinary Liver-Type Fatty Acid Binding Protein as a Postoperative Marker of Acute Kidney Injury in Patients Undergoing EndovascularAortic Aneurysm Repair
Authors' conclusion
Urinary L-FABP is emerging as a sensitive biomarker for AKI in patients undergoing EVAR.
Study context
- Population
- Hospitalised patients with abdominal aortic aneurysm (AAA) undergoing EVAR, 4 university hospitals, January–June 2024
- Participants
- 59 patients
- Exposure
- Positive vs negative urinary L-FABP after EVAR
- Outcome
- Positive L-FABP rate and association with renal outcomes
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Positive L-FABP at 6 h post-EVAR
- 24.1%
- Positive L-FABP at 24 h post-EVAR
- 23.7%
- Positive L-FABP at both time points associated with higher postoperative serum creatinine (SCr) and lower estimated glomerular filtration rate (eGFR)
- p ≤ 0.015
- Positive L-FABP associated with reduced urine output (6 h; 24 h)
- p = 0.009 and p < 0.001
- Positive L-FABP associated with shorter hospital length of stay (LOS) (6 h; 24 h)
- p = 0.004 and p = 0.013
Observational data: associations, not effects.
Further findings
Prediction of reduced diuresis by models incorporating L-FABP
- Accuracy up to
- 86.1%
Prediction of LOS
- L-FABP at 6 h and 24 h predicted LOS; SCr and eGFR did not
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Urinary Liver-Type Fatty Acid Binding Protein as a Postoperative Marker of Acute Kidney Injury in Patients Undergoing EndovascularAortic Aneurysm Repair. J Cardiothorac Vasc Anesth. Published 13 August 2025. doi:10.
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