Cardiothoracic & vascular anesthesia

Use of rocuronium and sugammadex for video-assisted thoracoscopic surgery is associated with reduced duration of chest tube drainage: a propensity score-matched analysis

Br J AnaesthPublished Retrospective cohort study

Authors' conclusion

During general anaesthesia for VATS, compared with cisatracurium and neostigmine, use of rocuronium and sugammadex was associated with a significant decrease in the incidence of postoperative delayed removal of the chest tube, atelectasis, and pulmonary consolidation.

Study context

Population
Patients undergoing video-assisted thoracoscopic surgery (VATS) after tracheal intubation under GA, with quantitative neuromuscular monitoring and one 24 Fr chest tube140 per group matched
Participants
151 vs 547
Exposure
Rocuronium and sugammadex vs cisatracurium and neostigmine
  • Rocuronium and sugammadexn = 151
  • Cisatracurium and neostigminen = 547reference
Outcome
Duration of chest tube drainage after surgery
Methodological detailssingle-centre, propensity-score matched
  • Single-centre
  • Propensity-score matched

Main finding

As reported in the abstract

P = 0.049

Observational data: associations, not effects.

Further findings

OutcomeOR (95% CI)P value
Delayed chest tube removal63% reduction0.37 (0.20–0.67)P = 0.005
OutcomeP value
Postoperative atelectasisLower incidenceP = 0.047
Postoperative consolidationLower incidenceP = 0.008

Delayed chest tube removal per 1 h increase in duration of anaesthesia

1.57-fold increase
1.57 (95% CI 1.25-1.96; P=0.005)

Original publication

Use of rocuronium and sugammadex for video-assisted thoracoscopic surgery is associated with reduced duration of chest tube drainage: a propensity score-matched analysis. Br J Anaesth. Published 26 August 2022. doi:10.1016/j.bja.2022.07.046

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