Cardiothoracic & vascular anaesthesia
Validation of intraoperative processed electroencephalography and cerebral oximetry for prediction of postoperative delirium in cardiac surgery: a prospective observational study
Authors' conclusion
This study suggests that the combined use of NIRS and pEEG monitoring is an innovative approach for predicting delirium and TPOD in patients undergoing cardiac surgery.
Study context
- Population
- Adults scheduled for cardiac surgeryincluded in analysis
- Participants
- 148 adults
- Outcome
- Incidence of four intraoperative states defined by combined processed electroencephalography (pEEG) and near-infrared spectroscopy (NIRS) (State 1: cerebral desaturation and Patient State Index (PSi) < 25 and/or suppression ratio (SR) > 0; State 2: cerebral desaturation with PSi ≥ 50 and SR = 0; State 3: cerebral desaturation with normal pEEG; State 4: normal cerebral saturation with PSi < 25 and/or SR > 0)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incidence of State 4
Patients spending more than 1 min in State 4
95%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Postoperative delirium by time in each state (logistic regression)Longer time in State 2 | 1.17 (1.00–1.38) | |
| Postoperative delirium by time in each state (logistic regression)Longer time in State 3 | 1.15 (1.03–1.29) | |
| Postoperative delirium by time in each state (logistic regression)Longer time in State 4 | 1.01 (1.00–1.02) | |
| 0.512Odds ratio (log scale) |
| Outcome | β coefficient (95% CI) |
|---|---|
| Time of persistent organ dysfunction (TPOD) by time in State 1 | 0.27 (0.07–1.60) |
Original publication
Validation of intraoperative processed electroencephalography and cerebral oximetry for prediction of postoperative delirium in cardiac surgery: a prospective observational study. Can J Anaesth. Published 19 August 2026. doi:10.
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