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Cardiac Arrest During Long-Distance Running Races
Cohort studyCardiac arrest
JAMA
Concordance of 30-Day Mortality and In-Hospital Mortality or Hospice Discharge After Sepsis
Cohort studySepsis & infection
JAMA
Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study
Cohort studySepsis & infection
JAMA
Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial
Randomised controlled trialSepsis & infection
JAMA
Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Randomised controlled trialTrauma & bleeding
JAMA
Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial
Randomised controlled trialPerioperative
JAMA
Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients: The TELESCOPE Randomized Clinical Trial
Randomised controlled trialICU sedation & recovery
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JAMA
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial
Randomised controlled trialNeuro
JAMA
Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial
Randomised controlled trialNeuro
JAMA
Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial
Randomised controlled trialCardiothoracic & vascular
JAMA
Tranexamic Acid in Patients Undergoing Liver Resection: The HeLiX Randomized Clinical Trial
Randomised controlled trialPerioperative
JAMA
Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial
Randomised controlled trialPerioperative
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Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial
Randomised controlled trialCardiothoracic & vascular
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Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial
Randomised controlled trialSepsis & infection
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Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial
Randomised controlled trialSepsis & infection
JAMA
Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial
Randomised controlled trialOrgan support & nutrition
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Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial
Randomised controlled trialCardiothoracic & vascular
JAMA
Preoperative GLP-1 Receptor Agonist Use and Risk of Postoperative Respiratory Complications
Cohort studyPerioperative
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Cardiac Function Before Sepsis and Clinical Outcomes
Cohort studySepsis & infection
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Video Laryngoscopy vs Direct Laryngoscopy for Endotracheal Intubation in the Operating Room: A Cluster Randomized Clinical Trial
Randomised controlled trialAirway
JAMA
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults
Secondary analysisRespiratory failure
JAMA
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
Cohort studySepsis & infection
JAMA
International Consensus Criteria for Pediatric Sepsis and Septic Shock
Guideline or statementSepsis & infection
JAMA
Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial
Randomised controlled trialAirway
JAMA
Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial
Randomised controlled trialRespiratory failure
JAMA
Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial
Randomised controlled trialTrauma & bleeding
JAMA
Red Blood Cell Transfusion: 2023 AABB International Guidelines
Guideline or statementHaemodynamics & fluids
JAMA
Red Blood Cell Transfusion in the Intensive Care Unit
Cohort studyHaemodynamics & fluids
JAMA
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial
Randomised controlled trialHaemodynamics & fluids
JAMA
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial
Randomised controlled trialTrauma & bleeding
JAMA
Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials
Randomised controlled trialOrgan support & nutrition
JAMA
Prevalence of Acinetobacter baumannii and Candida auris in Patients Receiving Mechanical Ventilation
Cross-sectional studySepsis & infection
JAMA
Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial
Randomised controlled trialSepsis & infection